Andrographis Extract
Latin Name: Andrographis paniculata (Burm. f.) Wall. ex Nees
Chinese Name: Chuan Xin Lian/穿心莲
Family: Acanthaceae
Part of the Plant Used: Herb (100% Natural)
Active Ingredients: Andrographolide
Product Introduction
Andrographolide is a diterpenoid lactone compound typically presenting as acicular or prismatic crystalline solids. As the principal bioactive constituent derived from Andrographis paniculata, this molecule exhibits thermolytic and anti-inflammatory properties through modulation of cytokine signaling pathways. Current research indicates potential applications in managing respiratory tract conditions. Characterized by low aqueous solubility (<0.1 mg/mL at 25°C), novel delivery systems including cyclodextrin complexes and nanoemulsions have been developed to enhance bioavailability. Key pharmacodynamic attributes include:
NF-κB Pathway Modulation: Downregulates pro-inflammatory mediators
Reactive Oxygen Species Scavenging: Demonstrates significant ORAC values (12,000 μmol TE/g)
Bacterial Adhesion Inhibition: Reduces pathogen colonization in vitro
Pharmaceutical applications primarily utilize oral administration, with enteric-coated formulations showing enhanced stability in gastric environments.
Physiological Functions
1. Anti-pathogenic microbial effect
2. Antipyretic effect
3. Anti-inflammatory effect
4. Effect on the body's immune function
5. Anti-fertility effect
6. Choleretic and hepatoprotective effect
7. Anti-tumor effect
Applications
Andrographolide is used for dysentery, leptospirosis, meningitis, pneumonia, enhancing adrenal cortex function, and upper respiratory tract infections. In response to the clinical needs for urgent viral infection treatments, different hydrophilic groups have been introduced into the structure of the product to enhance its water solubility and improve efficacy. As a result, various Andrographolide injections have been developed, with the widely used Chuanhun Ning injection, Yanhu Ning injection, and Lianbi Zhi injection being representative drugs in this category. These have been listed as essential medications in emergency departments by the Ministry of Health and the State Administration of Traditional Chinese Medicine.
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